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KMID : 0390220150260020230
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2015 Volume.26 No. 2 p.230 ~ p.235
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Diagnostic Effectiveness of Minor Salivary Gland Biopsy for Sjogren’s Syndrome
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강보성:Kang Bo-Sung
김재욱:Kim Jae-Wook
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Abstract
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Background：Sjogren’s syndrome is difficult to diagnose. Because several tools for exact diagnosis have been made over the decades. However none of them is both sensitive and specific. American College of Rheumatology (ACR) issued new diagnostic criteria based on only three objective tests in 2012. These are immunoserologic test, minor salivary gland biopsy, ocular staining test. We analyzed diagnostic effectiveness of minor salivary gland biopsy in suggesting Sjogren’s syndrome patients based on ACR guideline.
Methods：We analyze 41 patients who suggesting Sjogren’s syndrome retrospectively about Immunoserologic results, minor salivary gland biopsy results, ocular staining test. Sensitivity and specificity of minor salivary gland biopsy was obtained.
Results：Minor salivary gland biopsy sensitivity was 70.8% and specificity, 100%, positive predictive value, 100%, negative predictive value, 70.8%. No salivary gland biopsy complication was noted in 41 patients.
Conclusions：Minor salivary gland biopsy is objective test and keyword method for Sjogren’s syndrome final diagnosis. High specificity can help physician to exclude normal people from Sjogren’s syndrome patients. Due to relatively invasive procedure and low sensitivity, this procedure could be recommended to last step for final diagnosis.
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KEYWORD
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Sjogren’s syndrome, Minor salivary gland biopsy
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